Lattice corneal dystrophy, gelsolin type (Meretoja’s syndrome)

Meretoja's Syndrome: Lattice Corneal Dystrophy, Gelsolin Type

Lattice corneal dystrophy gelsolin type was first described in 1969 by Jouko Meretoja, a Finnish ophthalmologist. It is caused by an autosomal dominant mutation in gelsolin gene resulting in unstable protein fragments and amyloid deposition in various organs. The age of onset is usually after the third decade of life and typical diagnostic triad includes progressive bilateral facial paralysis, ...

recurrent amyloid material in grafts used in patients with lattice corneal dystrophy 2 (meretoja’s syndrome)

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Lattice corneal dystrophy: a source of confusion.

Published descriptions of families with lattice dystrophy of the cornea reveal a much more varied clinical course and a more pleomorphic corneal picture than the rather stereotyped textbook descriptions would suggest. This report describes a family with lattice dystrophy of unusually late onset with retention of useful vision into the 7th decade. Herpes simplex keratitis was misdiagnosed in 5 m...

Corneal elastosis within lattice dystrophy lesions.

Corneal buttons of two patients with lattice corneal dystrophy were studied by light and electron microscopy. They showed elastotic degeneration within the amyloid deposits. The amyloid deposits displayed characteristic staining; the elastotic material (elastin) within the deposits stained positive with Verhoeff-van Gieson and Movat pentachrome stains and showed autofluorescence. The characteri...

Corneal dystrophy in Cockayne's syndrome.